Optimum healing of a cutaneous wound involves a cascade of biologic cellular and molecular
processes. When the normal biological process fails for any reason, healing process can cease resulting
in chronic wounds. In Addition, the body cannot repair some extensive wou More
Optimum healing of a cutaneous wound involves a cascade of biologic cellular and molecular
processes. When the normal biological process fails for any reason, healing process can cease resulting
in chronic wounds. In Addition, the body cannot repair some extensive wounds without problem.
These Issues surrounding wound healing as well as increased medical healthcare in this field,
developed novel wound therapies. Regardless of the type of these specific advanced wound care
methods, the ideal goal would be to regenerate tissues such that both the structural and functional
properties of the wounded tissue are restored to the levels before injury. Tissue engineering and stem
cells may be the solution. A range of cell based therapies and tissue engineered scaffolds have begun
to cross the rift from bench to bedside. These therapies have been heralded as a promising means by
which to surpass current limitations in wound management. The wide differentiation potential of
stem cells allows for the possibility of regenerating lost or damaged skin, while their ability to
immunomodulate the wound bed from afar suggests that their clinical applications need not be
restricted to direct tissue formation. The data suggests that the appropriate application of stem cells
and scaffolds can accelerate wound healing. The clinical utility of stem cells and tissue engineering has
been demonstrated across dozens of clinical trials in wound therapy.
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Tendon tissue has limited regeneration potential and usually the consequent formation of scar tissue causes inferior mechanical properties. Nanoparticles could be used in different way to improve tendon healing and regeneration, ranging from scaffolds manufacturing (inc More
Tendon tissue has limited regeneration potential and usually the consequent formation of scar tissue causes inferior mechanical properties. Nanoparticles could be used in different way to improve tendon healing and regeneration, ranging from scaffolds manufacturing (increasing the strength and endurance or anti-adhesions, anti-microbial, and ante inflammatory properties) to gene therapy. This paper aims to summarize the most relevant studies showing the potential application of nanoparticles for tendon tissue regeneration.
Manuscript profile
